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KMID : 0043319940170030175
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Archives of Pharmacal Research
1994 Volume.17 No. 3 p.175 ~ p.181
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Rapid Gas Chromatographic Profiling and Screening of Acidic Non-Steroidal Antiinflammatory Drugs in Biological Samples
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Kim Kyoung-Rae
Shin You-Jin
Shim Won-Hee
Myung Seoung-Won
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Abstract
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The solid-phase extraction (SPF) with subsequent tert-butyldimethylsilyl (TBDMS) derivatization was investigated for the rapid profiling and screening of various carboxylated non-steroidal antiinflammatory drugs (NSAIDs) simultaneously in biological fluid samples. Compared to the conventional SPF in adsorption mode using Chromosorb 102, Chromosorb 107, Carbopak B and Thermosorb, the SPF in partition mode using Chromosorb P as the adsorbent, and ethyl acetate/methylene chloride as the eluting solvents provided hightest overall recovenies of the NSAIDs from aqueous solutions with good precision. The solid-phase extracted NASIDs were silylated with N-methyl-N-(tert-butyldimethylsily)trifuoroacetamide to TBDMS derivatives and directly analyzed by capillary gas chromatography and gs chromatography-mass spectrometry. The usefulness of the present method was examined for the profilling and screening of saliva, serum and urine samples for various NSAIDs simultaneously.
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KEYWORD
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NSAIDs, Solid-phase extraction, Chromosorb P, TBDMS derivatization, Screening Biological sample
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